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• As Wnt/ß-catenin signaling is necessary for behavioral resilience to chronic social defeat stress (Dias et al., 2014), downregulation of this pathway may contribute to enhanced female vulnerability to SCVS.
• Our finding of minimal overlap in genes, miRs, and functional processes between the sexes suggests that the female transcriptional and post-transcriptional stress response is not a blunted male response, but is rather a fundamentally different, sex-specific response.
• Alternatively, as the effect of a single miR on target expression is modest, the net effect of all targeting miRs on a gene may be negative despite some positive miR-mRNA relationships.
• In initial experiments the use of tissue histological techniques was examined for hydrogel visualization (data not shown).

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• Yet while IBM’s claims have not yet been peer-reviewed, Google published its results in the journal Nature yesterday.
• In order to accomplish this, we identified all mRNA targets of SCVS-regulated miRs predicted by both TargetScan and miRWalk online databases (Lewis et al., 2005).

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The reviewer MF and handling Editor declared their shared affiliation, and the handling Editor states that the process nevertheless met the standards of a fair and objective review. This actually offers a nice heuristic for making quantitative predictions about prime numbers, known as the “Cramér random model”, named for 20th-century Swedish mathematician Harald Cramér. In this model, you treat the prime numbers as if they came from a random distribution where each number $n$ has a probability of $1 / \ln(n)$ of being included. One must obviously take this with a heavy grain of salt since the primes are not random, but the idea is that many they exhibit many of the statistical patterns you might expect from such a distribution.

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